What is the most likely diagnosis?
- 43 year-old mild shortness of breath
Axial non-enhanced CT Images of the Lower Chest
- Silicosis
- Sarcoidosis
- Smoke inhalation
- Lipoid pneumonia
- Pulmonary alveolar microlithiasis
Additional Images - Frontal chest radiograph
Additional Images
Frontal chest radiograph
Answer:
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5. Pulmonary Alveolar Microlithiasis
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Pulmonary Alveolar Microlithiasis
General Considerations
- Very rare, chronic disease characterized by widespread calcifications called "calcispherites" within the alveoli
- Etiology is unknown but it has a familial incidence with an autosomal recessive inheritance pattern
- No known calcium metabolism disorder
- Microliths range from 0.01 to 3 mm in size and are composed of calcium phosphate
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